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21 February 2019 Non-destructive real-time monitoring of brain tumor exception by combining high-frequency ultrasounds with infrared spectroscopy
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Abstract
The purpose of the current paper is the development of a non-destructive imaging system for diagnostic purposes, consisting of ultrasonic transducers of high frequency and an infrared spectrometer, enabling the monitoring of the brain spatial variation and the detection of cancerous cells spreading to healthy tissues during the neurosur- gical tumor exception. Ultrasound utilization during the neurosurgery, where a part of the skull is temporarily removed, is able to provide a new perspective on the imaging techniques. The proposed device combines trans- ducers of different center frequencies in order to achieve sufficient penetration depth inside the brain and fine spatial resolution. Moreover, the infrared spectroscopy technique is utilized and combined with the ultrasound to achieve the recognition of the cancerous cells from their infrared fingerprint. The drawback of the poor penetration depth of the infrared electromagnetic waves is overcome by inserting a small diameter probe near the location of the main tumor. The probe is integrated into the same structure as the ultrasound device to receive both signals from the identical spot. Finally, advanced signal processing techniques are used to maximize separately the information of the independent systems, while the data fusion will be attempted.
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© (2019) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Georgios Th. Karagiannis, Stamatios A. Amanatiadis, and Georgios K. Apostolidis "Non-destructive real-time monitoring of brain tumor exception by combining high-frequency ultrasounds with infrared spectroscopy", Proc. SPIE 10883, Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXVI, 108830Z (21 February 2019); https://doi.org/10.1117/12.2510451
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