Spectral region beyond 1.7 μm is particularly interesting for biomedical spectroscopic sensing applications due to the presence of strong and molecule-specific ro-vibrational overtone and combination absorption bands for a number of important analytes such as glucose, lactate, urea, human serum albumin among others. However, this spectral region has been largely unexplored for applications targeting wearable device technology due to the absence of commercially available semiconductor light source technology. In this work we report on recent progress in developing beyond-stateof-the-art GaSb-based swept-wavelength laser technology as a key building-block of the proposed spectroscopic sensor concept. To demonstrate the capability of the technology, we provide experimental data of in vitro sensing concentrations down to the normal physiological range and beyond for glucose, lactates, urea and bovine serum albumin. Furthermore, we provide initial experimental evidence of non-invasive in vivo sensing experiment with extracted absorbance signature of human serum albumin collected from the wrist and demonstrate a clear path towards sensing other analytes. Finally, to demonstrate the full potential of the spectroscopic sensor technology for the wearable device market, we present results of our initial effort to realize a complete spectroscopic sensor system-on-a-chip based on hybrid GaSb/Si material platform and manufactured using conventional 200 mm silicon-on-insulator CMOS technology process in a commercial high-volume foundry.