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20 February 2019 Temperature near-infrared absorption spectrum monitoring for in vivo tissue based on a new scattering-independent measurement
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Abstract
We present a scattering-independent measurement to monitor the pure near-infrared light absorption variation for scattering media, especially for in vivo tissue. We found a scattering variation independent source-detector separation (SVI-SDS), where the diffuse light intensity only varies with tissue absorption change but does not vary with scattering change. We applied the SVI-SDS setup to monitor the tissue spectra with a temperature modulation. We also proposed a method to simplify the measurement by using two fixed SDSs for all wavelengths. It makes the detection device easy to design and fit to the required SVI-SDSs. Monte Carlo simulation and experiments on intralipid solutions and in vitro pig skin samples are performed to test the method. The temperature absorption spectra were acquired, and the temperature insensitive wavelengths of the tissue are discussed. We believe this new method will guide many potential applications for the absorption-based tissue spectroscopy.
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Jin Liu, Lingxing Guo, Xueyu Liu, Tongshuai Han, and Kexin Xu "Temperature near-infrared absorption spectrum monitoring for in vivo tissue based on a new scattering-independent measurement", Proc. SPIE 10885, Optical Diagnostics and Sensing XIX: Toward Point-of-Care Diagnostics, 108850X (20 February 2019); https://doi.org/10.1117/12.2508111
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