Terahertz pulse time-domain holography method for phase imaging of breast tissue

Nikolay S. Balbekin; Quentin Cassar; Olga A. Smolyanskaya; Maksim S. Kulya; Nikolay V. Petrov; Gaetan MacGrogan; Jean-Paul Guillet; Patrick Mounaix; Valery V. Tuchin

doi:10.1117/12.2508711

4 March 2019 Terahertz pulse time-domain holography method for phase imaging of breast tissue

Nikolay S. Balbekin, Quentin Cassar, Olga A. Smolyanskaya, Maksim S. Kulya, Nikolay V. Petrov, Gaetan MacGrogan, Jean-Paul Guillet, Patrick Mounaix, Valery V. Tuchin

Author Affiliations +

Proceedings Volume 10887, Quantitative Phase Imaging V; 108870G (2019) https://doi.org/10.1117/12.2508711
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Pulse holographic imaging along with time-domain spectroscopy scan and tomographic techniques are of great interest. Since the advantages of holography are the lack of focusing optics and high spatial resolution, and, comparing with tomography, less computation cost for numerical reconstruction, this technique is preferable for the analysis of thin histological samples. In this work we have created the experimental scheme that involves measurement of diffraction pattern of the collimated THz pulse field spatial distribution at some distance behind the object in the time-domain mode, thus allowing reconstruction of amplitude and phase distribution at the object plane by numerical backpropagation of the wavefront in the spectral domain. In our experiment, we used a breast biopsy sample containing cancer tissues, we also performed numerical simulations accounting for experimental conditions to confirm the conceptual applicability of the reconstruction method.

Conference Presentation

Citation Download Citation

Nikolay S. Balbekin, Quentin Cassar, Olga A. Smolyanskaya, Maksim S. Kulya, Nikolay V. Petrov, Gaetan MacGrogan, Jean-Paul Guillet, Patrick Mounaix, and Valery V. Tuchin "Terahertz pulse time-domain holography method for phase imaging of breast tissue", Proc. SPIE 10887, Quantitative Phase Imaging V, 108870G (4 March 2019); https://doi.org/10.1117/12.2508711

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available