Extending the wavelength range of multi-spectral microscope systems with Fourier ptychography

Antony Chi Shing Chan; Cheng Shen; Elliott Williams; Xiaoyu Lyu; Hangwen Lu; Craig Ives; Ali Hajimiri; Changhuei Yang

doi:10.1117/12.2510875

25 March 2019 Extending the wavelength range of multi-spectral microscope systems with Fourier ptychography

Antony Chi Shing Chan, Cheng Shen, Elliott Williams, Xiaoyu Lyu, Hangwen Lu, Craig Ives, Ali Hajimiri, Changhuei Yang

Proceedings Volume 10890, Label-free Biomedical Imaging and Sensing (LBIS) 2019; 108902O (2019) https://doi.org/10.1117/12.2510875
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

Due to the chromatic dispersion properties inherent in all optical materials, even the best designed multi-spectral objective will exhibit residual chromatic aberration effect. Here we show that the aberration correction ability of Fourier Ptychographic Microscopy (FPM) is well matched and well suited for post-image acquisition correction of these effects to render in-focus images. We show that an objective with significant spectral focal shift (up to 0.02 μm/nm) and spectral field curvature (up to 0.05 μm/nm drift at off-axis position of 800μm) can be computationally corrected to render images with effectively null spectral defocus and field curvature. This approach of combining optical objective design and computational microscopy provides a good strategy for high quality multi-spectral imaging over a broad spectral range, and eliminating the need for mechanical actuation solutions.

Citation Download Citation

Antony Chi Shing Chan, Cheng Shen, Elliott Williams, Xiaoyu Lyu, Hangwen Lu, Craig Ives, Ali Hajimiri, and Changhuei Yang "Extending the wavelength range of multi-spectral microscope systems with Fourier ptychography", Proc. SPIE 10890, Label-free Biomedical Imaging and Sensing (LBIS) 2019, 108902O (25 March 2019); https://doi.org/10.1117/12.2510875

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