CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 10891 > Article
Presentation
4 March 2019 Surface-enhancement Raman scattering of urine for prostate cancer risk assessment (Conference Presentation)
Yiwei Ma, Liu Kai, Isaac Y. Kim, Henry Du
Author Affiliations +
Proceedings Volume 10891, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI; 1089111 (2019) https://doi.org/10.1117/12.2510265
Event: SPIE BiOS, 2019, San Francisco, California, United States
Abstract
Prostate cancer is a heterogenous disease that has a varied range from indolent to highly aggressiveness. The routinely used biomarker, Prostate Specific Antigen (PSA), is controversial due to over-diagnosis. A new approach is urgently needed to discriminate the indolent and lethal prostate cancer. We report the measurements of patient urine using surface-enhancement Raman scattering (SERS) as a potential means of differentiating aggressive and indolent prostate cancer types. To this end, urine samples from twenty prostate cancer patients with known clinical outcome are investigated in this study, with ten in each of the two groups: aggressive and indolent. SERS measurements, ten for each sample, are carried out in blind without revealing any clinical details to the investigators. Principal component analysis (PCA) and linear discriminant analysis (LDA) are used to statistically analyze the large number of Raman spectra to identify and classify the specific Raman features potentially associated with aggressive and indolent prostate cancer types. The experimental classifications are compared with the clinical outcome of the prostate cancer patients to demonstration the potential of SERS as an alternative method for patient screening and decision-making for the optimal treatment strategy.
Conference Presentation
© (2019) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Yiwei Ma, Liu Kai, Isaac Y. Kim, and Henry Du "Surface-enhancement Raman scattering of urine for prostate cancer risk assessment (Conference Presentation)", Proc. SPIE 10891, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI, 1089111 (4 March 2019); https://doi.org/10.1117/12.2510265
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Prostate cancer
Raman scattering
Principal component analysis
Raman spectroscopy
Statistical analysis
Prostate
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top