Highly stable conjugated polymer dots as multifunctional agents for photoacoustic imaging-guided photothermal therapy

Zhen Yuan; Kaiwen Chang

doi:10.1117/12.2508296

5 March 2019 Highly stable conjugated polymer dots as multifunctional agents for photoacoustic imaging-guided photothermal therapy

Zhen Yuan, Kaiwen Chang

Author Affiliations +

Proceedings Volume 10891, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI; 1089113 (2019) https://doi.org/10.1117/12.2508296
Event: SPIE BiOS, 2019, San Francisco, California, United States

Abstract

The development of multifunctional organic nanomaterials is extremely essential for their in vivo cancer theranostic applications. In this study, we report a new BDT-IID based conjugated polymer dots (Pdots) platform that can serve as multifunctional nanoprobes for photoacoustic (PA) imaging-guided photothermal therapy (PTT). The novel BDT-IID Pdots are readily fabricated though nanoreprecipitation and can absorb strongly in the near-infrared region (NIR, 650-700 nm). Furthermore, BDT-IID Pdots possess the stable nanostructure and extremely low biotoxicity. In particular, its photothermal conversion efficiency can be up to 45%. More importantly, our in vivo results exhibit that the BDT-IID Pdots are able to offer concurrently enhanced PA imaging signals and sufficient photothermal effect. Consequently, the BDT-IID Pdots can be exploited as a unique theranostic nanoplatform for PA imaging-guided PTT of tumors, holding great promise for their clinical translational development.

Conference Presentation

Citation Download Citation

Zhen Yuan and Kaiwen Chang "Highly stable conjugated polymer dots as multifunctional agents for photoacoustic imaging-guided photothermal therapy", Proc. SPIE 10891, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XVI, 1089113 (5 March 2019); https://doi.org/10.1117/12.2508296

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