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7 March 2019 DNA: Gold nanoparticles designed for mRNA sensing in cells: imaging of the gold nanoparticles using two photon photoluminescence spectroscopy.
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Abstract
Recently DNA-coated gold nanoparticles have emerged as ideal tools for the detection of mRNA in cells using dye modified oligonucleotides. However, the tracking of the gold core has been hindered by the small size of the particle core. In this work we utilize a home built set up and 43 nm DNA-coated spherical gold nanoparticles for the simultaneous imaging of mRNA detection using fluorescence microscopy and the gold nanoparticle core using two photon photoluminescence (TPPL).
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Maria-Eleni Kyriazi, Otto L. Muskens, and Antonios G. Kanaras "DNA: Gold nanoparticles designed for mRNA sensing in cells: imaging of the gold nanoparticles using two photon photoluminescence spectroscopy.", Proc. SPIE 10892, Colloidal Nanoparticles for Biomedical Applications XIV, 108920C (7 March 2019); https://doi.org/10.1117/12.2502724
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