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1 May 1989 NIKOS II - A System For Non-Invasive Imaging Of Coronary Arteries
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This paper presents results of the initial in-vivo investigations with the system NIKOS II (NIKOS = Nicht-invasive Koronarangiographie mit Synchrotronstrahlung), an advanced version of NIKOS I which was developed since 1981. Aim of the work is to be able to visualize coronary arteries down to 1mm diameter with an iodine mass density of lmg/cm2, thus allowing non-invasive investigations by intravenous injection of the contrast agent. For this purpose Digital Subtraction Angiography (DSA) in energy subtraction mode (dichromography) is employed. The two images for subtraction are taken at photon energies just below and above the iodine K-edge (33.17keV) After subtraction the background contrast from bone and soft tissue is suppressed and the iodinated structures are strongly enhanced because of the abrupt change of absorption at the K-edge. The two monoenergetic beams are filtered out of a synchrotron radiation beam by a crystal monochromator and measured with a two line detector. One scan (two images) lasts between 250ms (final version) and ls (at present ). The images from the in-vivo investigations of dogs have been promising. The right coronary artery (diameter 1.5mm) was clearly visible. With application of better image processing algorithms the images illustrated in this paper have a definite potential for improvement.
© (1989) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
W.-R. Dix, K. Engelke, G. Heintze, J. Heuer, W. Graeff, W. Kupper, M. Lohmann, I. Makin, T. Mochel, and R. Reumann "NIKOS II - A System For Non-Invasive Imaging Of Coronary Arteries", Proc. SPIE 1090, Medical Imaging III: Image Formation, (1 May 1989);

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