Neural networks and expert systems provide different ways to reduce the programming effort required to build complex systems. Adaptive neural networks are programmed merely by training them with examples. Rule-based expert system are developed incrementally merely by adding rules. Although neural networks seem best suited for low-level sensory processing and expert systems seem best suited for high-level symbolic processing, strikingly similar issues arise when these approaches are used in large-scale applications. Illustrative examples of such applications are presented and discussed.