Computerized assessment of glaucoma severity based on color fundus images

Lei Wang; Han Liu; Jian Zhang; Hang Chen; Jiantao Pu

doi:10.1117/12.2510446

15 March 2019 Computerized assessment of glaucoma severity based on color fundus images

Lei Wang, Han Liu, Jian Zhang, Hang Chen, Jiantao Pu

Proceedings Volume 10953, Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging; 1095322 (2019) https://doi.org/10.1117/12.2510446
Event: SPIE Medical Imaging, 2019, San Diego, California, United States

Abstract

In this study, the deep learning technology was used to grade the severity of glaucoma depicted on color fundus images. We retrospectively collected a dataset of 5,978 fundus images acquired on different subjects and their glaucoma severities were annotated as none, mild, moderate, or severe, respectively, by the consensus of two experienced ophthalmologists. These images were preprocessed to generate global and local regions of interest (ROIs), namely the global field-of-view images and the local disc region images. These ROIs were separately fed into eight classical convolutional neural networks (CNNs) (i.e., VGG16, VGG19, ResNet, DenseNet, InceptionV3, InceptionResNet, Xception, and NASNetMobile) for classification purposes. Experimental results demonstrated that the available CNNs, except VGG16 and VGG19, achieved average quadratic kappa scores of 80.36% and 78.22% when trained from scratch on global and local ROIs, and 85.29% and 82.72% when fine-tuned using the imagenet weights, respectively. VGG16 and VGG19 achieved reasonable accuracy when trained from scratch, but they failed when using imagenet weights for both global and local ROIs. Among these CNNs, DenseNet had the highest classification accuracy (i.e., 75.50%) based on pre-trained weights when using global images, as compared to 65.50% when using local optic disc images.

Citation Download Citation

Lei Wang, Han Liu, Jian Zhang, Hang Chen, and Jiantao Pu "Computerized assessment of glaucoma severity based on color fundus images", Proc. SPIE 10953, Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging, 1095322 (15 March 2019); https://doi.org/10.1117/12.2510446

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