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18 March 2019 Colorectal tumor identification by transferring knowledge from pan-cytokeratin to H&E
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Abstract
Tumor budding is a recently recognized, independent prognostic factor in colorectal cancer, but lacks a standardized assessment methodology. Although staining with pan-cytokeratin has been shown to mitigate the issue of lack of reproducible, intra-observer agreement, usage of this antibody remains expensive and is limited in clinical practice. We propose an automated image analysis framework to take advantage of the visual superiority of pan-cytokeratin and the routine use of H&E to detect and quantify tumor budding. Our framework has demonstrated promising ability to identify tumor regions of colorectal slides – 92.0% accuracy, 94.5% sensitivity, and 85% specificity – across four independent datasets.
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Thomas E. Tavolara, Muhammad Khalid Khan Niazi, Wei Chen M.D., Wendy Frankel M.D., and Metin N. Gurcan "Colorectal tumor identification by transferring knowledge from pan-cytokeratin to H&E", Proc. SPIE 10956, Medical Imaging 2019: Digital Pathology, 1095614 (18 March 2019); https://doi.org/10.1117/12.2513014
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