Analysis of small vessel cochlear blood flow regulation during loud sound exposure in the mouse

George W. S. Burwood; Suzan Dziennis; Teresa Wilson; Jianlong Yang; Gangjun Liu; Sarah Foster; Ruikang Wang; Alfred L. Nuttall

doi:10.1117/12.2505434

15 November 2018 Analysis of small vessel cochlear blood flow regulation during loud sound exposure in the mouse

George W. S. Burwood, Suzan Dziennis, Teresa Wilson, Jianlong Yang, Gangjun Liu, Sarah Foster, Ruikang Wang, Alfred L. Nuttall

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Proceedings Volume 10964, Tenth International Conference on Information Optics and Photonics; 109641R (2018) https://doi.org/10.1117/12.2505434
Event: Tenth International Conference on Information Optics and Photonics (CIOP 2018), 2018, Beijing, China

Abstract

Using optical coherence tomography angiography, we measured blood flow from the vessels in the lateral wall in the mouse cochlea directly through bone in mice with and without sympathetic neuronal function. We present in vivo imaging of blood flow and mechanical vibration in mice subjected to 30 min of loud sound. Loud sound caused blood flow reduction. In mice with superior cervical ganglion ablation, the loud sound-induced reduction in blood flow was partially ameliorated. These results demonstrate that sympathetic innervation likely plays a role in the pathological decrease in blood flow observed in the lateral wall vessels in response to loud sound.

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George W. S. Burwood, Suzan Dziennis, Teresa Wilson, Jianlong Yang, Gangjun Liu, Sarah Foster, Ruikang Wang, and Alfred L. Nuttall "Analysis of small vessel cochlear blood flow regulation during loud sound exposure in the mouse", Proc. SPIE 10964, Tenth International Conference on Information Optics and Photonics, 109641R (15 November 2018); https://doi.org/10.1117/12.2505434

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KEYWORDS

Blood circulation

Optical coherence tomography

Supercontinuum generation

Ear

Angiography

Scanning probe lithography

Capillaries

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