Natural disasters, such as hurricanes, cyclones, and other high-speed windstorm events, pose a threat to the built environment. The damage of the nonstructural components due to high winds, flooding, hurricane surge and rainwater intrusion surrounding a building structure such as the fa¸cade accounts for the majority of the financial loss. The increased interest in the sustainable design of buildings gives forward to the development of creative low energy alternatives for the adaptive fa¸cade. This paper studies five fa¸cade configurations subjected to wind loading. An adaptive diagrid fa¸cade (ADF) is modeled using a panel system of four equilateral triangles: one panel is actuated at the nodes using linear actuators and controls the other three panels in the system. The proposed ADF can be adapted to fit various building heights and shapes and can be chosen due to their structural efficiency that results in material savings and flexibility in designing of complex buildings. This paper makes advances towards an adaptive origami-inspired diagrid fa¸cade has the potential to redistribute wind loads in real-time. With sustainable design becoming an important factor in design, low energy options for the adaptive fa¸cades were considered. This research performs computational fluid dynamic analysis of five threedimensional building structures: a conventional regular building structure, a diagrid building structure without corner columns, and three origami-inspired fa¸cade configurations on diagrid building structures. The purpose of this study is to understand effects of the different building envelope geometries on the fluid dynamics and explore the potential use in optimal shape configuration for real-time morphing adaptation of high-rise buildings subjected to extreme wind loading.