Sulcal-based morphometry in Parkinson’s disease: a study of reliability and disease effects

Fabrizio Pizzagalli; Guillaume Auzias; Armand Amini; Joshua Faskowitz; Faisal Rashid; Daniel Moyer; Peter Kochunov; Denis Rivière; Jean-François Mangin; Paul M. Thompson; Neda Jahanshad

doi:10.1117/12.2511590

21 December 2018 Sulcal-based morphometry in Parkinson’s disease: a study of reliability and disease effects

Fabrizio Pizzagalli, Guillaume Auzias, Armand Amini, Joshua Faskowitz, Faisal Rashid, Daniel Moyer, Peter Kochunov, Denis Rivière, Jean-François Mangin, Paul M. Thompson, Neda Jahanshad

Author Affiliations +

Proceedings Volume 10975, 14th International Symposium on Medical Information Processing and Analysis; 109750T (2018) https://doi.org/10.1117/12.2511590
Event: 14th International Symposium on Medical Information Processing and Analysis, 2018, Mazatlán, Mexico

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder in which patients show progressively worsening motor symptoms, often followed by cognitive impairment and dementia. Brain MRI can be used to identify patterns of neurodegeneration that are characteristic of PD, but the spatial pattern of brain abnormalities is still not well understood. “Sulcus-based morphometry” provides measures of the cortical fissures of the brain that reflect degenerative changes in relation to neuropsychiatric disease. Extracting sulci requires good contrast between the gray matter and the CSF, and less well-defined sulci may be difficult to extract reliably. Before embarking on a study of sulcal abnormalities in PD, we set out to determine the reliability of measures from 123 sulci, defined by an existing atlas, using publicly available test-retest data from 8 cohorts. Of the 123 atlas-defined sulci, several major sulci were broken down into smaller regions (e.g., the superior temporal sulcus was divided into the main STS, the anterior terminal ascending branch of STS and the posterior terminal ascending branch of STS); we assessed reliability in each individually, and after merging the portions of the sulci together, in a newly defined, concatenated atlas. For 467 subjects from the PPMI cohort (http://www.ppmiinfo. org ;age range: 61.5 ± 10.1 years), we segmented and labeled major sulci and extracted 4 shape descriptors for each: length, depth, surface area, and width. We then aimed to establish the profile of case-control differences for 3 candidate sulci of interest: the central sulcus, superior temporal sulcus and the calcarine fissure. These sulci were among the more robust in terms of reproducibility; we found that the calcarine width was associated with PD, offering new features for genetic and interventional studies of PD.

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Fabrizio Pizzagalli, Guillaume Auzias, Armand Amini, Joshua Faskowitz, Faisal Rashid, Daniel Moyer, Peter Kochunov, Denis Rivière, Jean-François Mangin, Paul M. Thompson, and Neda Jahanshad "Sulcal-based morphometry in Parkinson’s disease: a study of reliability and disease effects", Proc. SPIE 10975, 14th International Symposium on Medical Information Processing and Analysis, 109750T (21 December 2018); https://doi.org/10.1117/12.2511590

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