Optoelectronic method for determinating the selective serotonin reuptake inhibitors antidepressants

Maria Gabriela Neicu; Radu Macovei; Paul Şchiopu; Marian Vlădescu; Ruxandra Populeanu; Gina Caragaea; Elena Truţă; Mihai Ionică

doi:10.1117/12.2324748

31 December 2018 Optoelectronic method for determinating the selective serotonin reuptake inhibitors antidepressants

Maria Gabriela Neicu, Radu Macovei, Paul Şchiopu, Marian Vlădescu, Ruxandra Populeanu, Gina Caragaea, Elena Truţă, Mihai Ionică

Author Affiliations +

Proceedings Volume 10977, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX; 109773H (2018) https://doi.org/10.1117/12.2324748
Event: Advanced Topics in Optoelectronics, Microelectronics and Nanotechnologies IX, 2018, Constanta, Romania

Abstract

Mass spectrometry is an optoelectronic method of identifying organic substances by comparing their mass spectrum of the analyte with the mass spectra deposited in the mass spectrum libraries of the system. High Pressure Liquid Chromatography (HPLC) coupled with Mass Spectrometry (MS) has as main objective the identification of drugs with a molecular molecule of less than 1500 amu (atomic mass units) [1]. To identify the biological products of antidepressants SSRIs have been deposited in the mass-spectra of the MI library, mass spectra obtained in a HPLC-MS interface with ElectroSpray Interface (ESI) or Atmospheric Pressure Chemical Ionization (APCI). In the paper are presented the mass spectra of selective serotonin reuptake inhibitors (SSRIs): citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine and sertraline, obtained on a HPLC system MS equipped with ESI or APCI.

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Maria Gabriela Neicu, Radu Macovei, Paul Şchiopu, Marian Vlădescu, Ruxandra Populeanu, Gina Caragaea, Elena Truţă, and Mihai Ionică "Optoelectronic method for determinating the selective serotonin reuptake inhibitors antidepressants", Proc. SPIE 10977, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX, 109773H (31 December 2018); https://doi.org/10.1117/12.2324748

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