Optoelectronic method for the screening and confirmation of hydroxyethyl starch in urine samples

Jeni-Carla Colev; Bogdan Berghes; Mihai Ionică

doi:10.1117/12.2323819

31 December 2018 Optoelectronic method for the screening and confirmation of hydroxyethyl starch in urine samples

Jeni-Carla Colev, Bogdan Berghes, Mihai Ionică

Proceedings Volume 10977, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX; 109773Y (2018) https://doi.org/10.1117/12.2323819
Event: Advanced Topics in Optoelectronics, Microelectronics and Nanotechnologies IX, 2018, Constanta, Romania

Abstract

Polysaccharide-based plasma volume expanders (PVEs) such as hydroxyethyl starch (HES) is on Prohibited List of World Anti-Doping Agency (WADA) because it can prevent dehydration and reduce haematocrit values to mask erythropoietin abuse. The aim of this study is to establish time consuming and reliable methods for doping control screening and confirmation of HES in urine samples. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) with the same column: 5μm Zorbax SB-C18 was used for detection and confirmation without further sample preparation. The method was validated for the parameters: specificity and matrix effect, limit of detection (250μg/mL), identification capability, carryover, robustness. The results of the both method were found to be suitable for the detection and confirmation of hydroxyethylstarch.

Citation Download Citation

Jeni-Carla Colev, Bogdan Berghes, and Mihai Ionică "Optoelectronic method for the screening and confirmation of hydroxyethyl starch in urine samples", Proc. SPIE 10977, Advanced Topics in Optoelectronics, Microelectronics, and Nanotechnologies IX, 109773Y (31 December 2018); https://doi.org/10.1117/12.2323819

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