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15 April 2019 Towards poly(D,L-lactic acid)-based biodegradable and biocompatible polymer optical fiber
Agnieszka Gierej, Maxime Vagenende, Adam Filipkowski, Bartlomiej Siwicki, Ryszard Buczynski, Hugo Thienpont, Sandra Van Vlierberghe, Thomas Geernaert, Peter Dubruel, Francis Berghmans
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Proceedings Volume 11029, Micro-structured and Specialty Optical Fibres VI; 110290K (2019) https://doi.org/10.1117/12.2524698
Event: SPIE Optics + Optoelectronics, 2019, Prague, Czech Republic
Abstract
We demonstrate a biodegradable and biocompatible unclad optical fiber made from poly(D,L-lactic acid) (PDLLA), which is a well-known and commercially available amorphous polyester. We first deal with the chemical and optical characterization of the bulk polymer material and we report on the influence of the processing on the molecular weight and thermal properties of the polymer, during both the preform preparation and the fiber drawing process. We then proceed to the optical characterization based on spectral attenuation measurements using the cutback method and dispersion measurements. We also determine the thermo-optic coefficient. Finally, we confirm the in vitro degradation in phosphate buffered saline (PBS) of our PDLLA fibers. From the results and considering that PDLLA is an FDAregulated material, we anticipate that our optical fibers are valid candidates for medical applications involving in vivo light delivery, such as for example photodynamic therapy.
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Agnieszka Gierej, Maxime Vagenende, Adam Filipkowski, Bartlomiej Siwicki, Ryszard Buczynski, Hugo Thienpont, Sandra Van Vlierberghe, Thomas Geernaert, Peter Dubruel, and Francis Berghmans "Towards poly(D,L-lactic acid)-based biodegradable and biocompatible polymer optical fiber ", Proc. SPIE 11029, Micro-structured and Specialty Optical Fibres VI, 110290K (15 April 2019); https://doi.org/10.1117/12.2524698
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KEYWORDS
Polymers
Signal attenuation
Polymer optical fibers
Optical fibers
Photodynamic therapy
Refractive index
In vitro testing
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