Paper
3 June 2019 Research and development of effective optical technologies for diagnostics in dermatology
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Proceedings Volume 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine; 1106505 (2019) https://doi.org/10.1117/12.2528700
Event: International Symposium on Optics and Biophotonics VI: Saratov Fall Meeting 2018, 2018, Saratov, Russian Federation
Abstract
Optical clearing of the human skin under the action of hyaluronic acid (HA) as an enhancer for optical clearing by polyethylene glycol (PEG-300) was studied in vivo by optical coherent tomography (OCT) method on the wavelength 930±5 nm. The results have showed an increase in the transparency of the epidermis at the optical depth of 50±5 μm by 44±9% within 15 min with the use of a solution of HA in combination with sonophoresis before application of PEG-300 to the skin surface. At the same time, when using PEG-300 without preliminary treatment of the skin with the HA, an increase in the transparency of the epidermis at the same depth was 21±8% within 25 min. In dermis at the depth of 500 μm the OCT signal in the experimental group increased more than 1.6 fold what indicates an increasing of optical probing depth.
© (2019) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Vadim D. Genin, Prisca Rakotomanga, Sergey M. Zaytsev, Elina A. Genina, Ekaterina N. Lazareva, Grégoire Khairallah, Marine Amouroux, Charles Soussen, Hang Chen, Wei Feng, Dan Zhu, Alexey N. Bashkatov, Walter Blondel, and Valery V. Tuchin "Research and development of effective optical technologies for diagnostics in dermatology", Proc. SPIE 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine, 1106505 (3 June 2019); https://doi.org/10.1117/12.2528700
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KEYWORDS
Skin

Optical coherence tomography

Tissue optics

Luminescence

In vivo imaging

Absorption

Scattering

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