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3 June 2019 Effect of different macromolecules on viscous and microrheologic properties of blood at various temperatures
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Proceedings Volume 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine; 1106507 (2019) https://doi.org/10.1117/12.2523688
Event: International Symposium on Optics and Biophotonics VI: Saratov Fall Meeting 2018, 2018, Saratov, Russian Federation
Abstract
Microrheological parameters of red blood cells (RBCs) and blood viscosity were studied by different optical and rheometric techniques. Measurements were performed under in vitro condition both on the EDTA-stabilized whole blood samples at various temperatures and on the RBCs in autologous serum without platelets at different concentrations of proaggregant macromolecules (Dextran 150, Dextran 500 and albumin). The nonlinear dependences of the aggregation parameters on the concentration of the proaggregant macromolecules in autologous serum were observed. Rheometry of human whole blood samples demonstrates a power law dependence of the suspension viscosity on temperature at such shear rates that allow the RBC aggregation. We assume that there may be an unaccounted temperature dependent synergetic effect of plasma proteins/macromolecules on RBC aggregation and interaction and, consequently, on the blood viscosity.
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Petr B. Ermolinskiy, Alexei N. Semenov, Andrei E. Lugovtsov, Christina Poeschl, Ursula Windberger, Efstathios Kaliviotis, and Alexander V. Priezzhev "Effect of different macromolecules on viscous and microrheologic properties of blood at various temperatures", Proc. SPIE 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine, 1106507 (3 June 2019); https://doi.org/10.1117/12.2523688
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