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3 June 2019 Photodynamic diagnostics for stomach cancer detection in stress modeled lesions in vivo
Ilana Agranovich, Alexander Khorovodov, Aysel Mamedova, Anastasia Shnitenkova, Veronika Shimanova, Nikita Navolokin, Tatiana Vashenko, Matvey Kanevsky, Anna Galitskaya, Svetlana Konnova, Ekaterina Borisova, Oxana Semyachkina-Glushkovskaya
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Proceedings Volume 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine; 110650B (2019) https://doi.org/10.1117/12.2520148
Event: International Symposium on Optics and Biophotonics VI: Saratov Fall Meeting 2018, 2018, Saratov, Russian Federation
Abstract
Gastric cancer is the main cause of death among oncological diseases of the gastrointestinal tract, which is associated with the difficulty of early diagnosis of this disease. This study aims to develop a new method for diagnosing gastric cancer using the delta-aminolevulinic acid / protoporphyrin IX photosensitizer (5-ALA / PpIX). The experiments were performed on white rats of average weight 250 grams. The animals were divided into 2 groups: control and experimental (stress + diet, including nitrites and carcinogenic amines) ones. The results of the studies, averaged for each type of tissue, clearly show significant differences between normal, precancerous and malignant changes in the stomach tissues of rats on the background of application of photodynamic diagnostics. The fluorescence from malignant neoplasms in the organ was maximal at 635 nm, which corresponds to the maximum emission of protoporphyrin due to the high accumulation of this photosensitizer in the affected tissues. The most important result of the study was the detection of precancerous changes (atrophic gastritis, confirmed by histological methods), using photodynamic diagnostics with photosensitizer 5-ALA / PpIX. Intensity of fluorescence in case of precancerous changes occupied an intermediate value between that in normal and in malignant mucosa of the stomach.
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Ilana Agranovich, Alexander Khorovodov, Aysel Mamedova, Anastasia Shnitenkova, Veronika Shimanova, Nikita Navolokin, Tatiana Vashenko, Matvey Kanevsky, Anna Galitskaya, Svetlana Konnova, Ekaterina Borisova, and Oxana Semyachkina-Glushkovskaya "Photodynamic diagnostics for stomach cancer detection in stress modeled lesions in vivo", Proc. SPIE 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine, 110650B (3 June 2019); https://doi.org/10.1117/12.2520148
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KEYWORDS
Cancer
Stomach
Diagnostics
Luminescence
Tissues
Tumor growth modeling
In vivo imaging
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