A comparison of terahertz optical constants and diffusion coefficients of tissue immersion optical clearing agents

Guzel R. Musina; Arsenii A. Gavdush; Daria K. Tuchina; Irina N. Dolganova; Gennady A. Komandin; Sergey V. Chuchupal; Olga A. Smolyanskaya; Olga P. Cherkasova; Kirill I. Zaytsev; Valery V. Tuchin

doi:10.1117/12.2526168

3 June 2019 A comparison of terahertz optical constants and diffusion coefficients of tissue immersion optical clearing agents

Guzel R. Musina, Arsenii A. Gavdush, Daria K. Tuchina, Irina N. Dolganova, Gennady A. Komandin, Sergey V. Chuchupal, Olga A. Smolyanskaya, Olga P. Cherkasova, Kirill I. Zaytsev, Valery V. Tuchin

Author Affiliations +

Proceedings Volume 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine; 110651Z (2019) https://doi.org/10.1117/12.2526168
Event: International Symposium on Optics and Biophotonics VI: Saratov Fall Meeting 2018, 2018, Saratov, Russian Federation

Abstract

We performed the transmission-mode terahertz (THz) pulsed spectroscopy of several THz-wave penetration- enhancing agents (PEAs): glycerol, propylene glycol, ethylene glycol, and polyethylene glycol, featuring the molecular weight of 200, 300 and 400. We vacuumized the THz beam path in order to reduce an impact of water vapor on measured data. We reconstructed optical properties and dielectric constants of the abovementioned PEAs in the spectral range of 0.1 to 2.5 THz. We analyzed measured THz optical properties along with the literature data for coefficients of PEAs' diffusion into tissues in order to objectively uncover strength and weaknesses of their use in the immersion optical clearing of tissues at THz frequencies.

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Guzel R. Musina, Arsenii A. Gavdush, Daria K. Tuchina, Irina N. Dolganova, Gennady A. Komandin, Sergey V. Chuchupal, Olga A. Smolyanskaya, Olga P. Cherkasova, Kirill I. Zaytsev, and Valery V. Tuchin "A comparison of terahertz optical constants and diffusion coefficients of tissue immersion optical clearing agents", Proc. SPIE 11065, Saratov Fall Meeting 2018: Optical and Nano-Technologies for Biology and Medicine, 110651Z (3 June 2019); https://doi.org/10.1117/12.2526168

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