In vivo optical clearing of human skin under the effect of aqueous solutions of some monosaccharides

K. V. Berezin; K. N. Dvoretsky; M. L. Chernavina; V. V. Nechaev; A. M. Lichter; V. V. Smirnov; E. M. Antonova; O. N. Grechukhina; M. V. Kartashov; V. V. Tuchin

doi:10.1117/12.2523317

3 June 2019 In vivo optical clearing of human skin under the effect of aqueous solutions of some monosaccharides

K. V. Berezin, K. N. Dvoretsky, M. L. Chernavina, V. V. Nechaev, A. M. Lichter, V. V. Smirnov, E. M. Antonova, O. N. Grechukhina, M. V. Kartashov, V. V. Tuchin

Author Affiliations +

Proceedings Volume 11066, Saratov Fall Meeting 2018: Laser Physics, Photonic Technologies, and Molecular Modeling; 110661D (2019) https://doi.org/10.1117/12.2523317
Event: International Symposium on Optics and Biophotonics VI: Saratov Fall Meeting 2018, 2018, Saratov, Russian Federation

Abstract

The results of in vivo optical immersion clearing of human skin under the effect of aqueous solutions of some immersion agents (monosaccharides of ribose, glucose and fructose, as well as glycerol, a triatomic alcohol) were obtained with the use of the OCT method. Values of average velocity of scattering coefficient change, obtained through an averaged Ascan of the OCT signal in the region of derma with the depth of 350 to 700 μm, were determined to evaluate the optical clearing efficiency. The velocity of scattering coefficient change and the optical clearing potential value appeared to be well correlated. The complex molecular modeling of a number of immersion clearing agents with a mimetic peptide of collagen (GPH)₃, carried out with the use of the methods of classical molecular dynamics and quantum chemistry, allowed to identify correlations between the optical clearing efficiency and such a property as the energy of intermolecular interaction of clearing agents with a collagen peptide fragment.

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K. V. Berezin, K. N. Dvoretsky, M. L. Chernavina, V. V. Nechaev, A. M. Lichter, V. V. Smirnov, E. M. Antonova, O. N. Grechukhina, M. V. Kartashov, and V. V. Tuchin "In vivo optical clearing of human skin under the effect of aqueous solutions of some monosaccharides", Proc. SPIE 11066, Saratov Fall Meeting 2018: Laser Physics, Photonic Technologies, and Molecular Modeling, 110661D (3 June 2019); https://doi.org/10.1117/12.2523317

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KEYWORDS

Optical clearing

Skin

Collagen

Scattering

Optical coherence tomography

Tissues

Hydrogen

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