Nanodiamond based complexes for prolonged dexamethasone release

Kirill A. Laptinskiy; Helene Kettiger; Olga A. Shenderova; Sergey A. Burikov; Jessica M. Rosenholm; Tatiana A. Dolenko

doi:10.1117/12.2523336

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3 June 2019 Nanodiamond based complexes for prolonged dexamethasone release

Kirill A. Laptinskiy, Helene Kettiger, Olga A. Shenderova, Sergey A. Burikov, Jessica M. Rosenholm, Tatiana A. Dolenko

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Proceedings Volume 11067, Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions; 110671G (2019) https://doi.org/10.1117/12.2523336
Event: International Symposium on Optics and Biophotonics VI: Saratov Fall Meeting 2018, 2018, Saratov, Russian Federation

Abstract

In the article for the first time the properties of nanodiamond complexes with dexamethasone obtained by two different approaches - attachment of the drug to the surface of nanodiamond and to the nanodiamond, covered by silica layer – were compared. It was found that the synthesized nanocomposite ND@silica@Dex is able to retain a greater amount of drug and allows achieving prolonged release of dexamethasone. These properties of the complexes ND@silica@Dex provide prospects for their use as drug carries.

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Kirill A. Laptinskiy, Helene Kettiger, Olga A. Shenderova, Sergey A. Burikov, Jessica M. Rosenholm, and Tatiana A. Dolenko "Nanodiamond based complexes for prolonged dexamethasone release", Proc. SPIE 11067, Saratov Fall Meeting 2018: Computations and Data Analysis: from Nanoscale Tools to Brain Functions, 110671G (3 June 2019); https://doi.org/10.1117/12.2523336

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