Novel strategy to increase specificity of ALA-induced PpIX accumulation through inhibition of transporters involved in ALA uptake

Hung Wei Lai; Ryuta Sasaki; Shiro Usuki; Motowo Nakajima; Tohru Tanaka; Shun-Ichiro Ogura

doi:10.1117/12.2524522

7 August 2019 Novel strategy to increase specificity of ALA-induced PpIX accumulation through inhibition of transporters involved in ALA uptake

Hung Wei Lai, Ryuta Sasaki, Shiro Usuki, Motowo Nakajima, Tohru Tanaka, Shun-Ichiro Ogura

Author Affiliations +

Proceedings Volume 11070, 17th International Photodynamic Association World Congress; 110706I (2019) https://doi.org/10.1117/12.2524522
Event: 17th International Photodynamic Association World Congress, 2019, Cambridge, Massachusetts, United States

Abstract

Aminolevulinic acid–based photodynamic therapy (ALA-PDT) has emerged as a new alternative for chemotherapy in cancer treatment due to its high specificity and low side effects. We added siRNAs and inhibitors of transporters to study the roles of transporters in ALA uptake in sets of normal and cancer cell lines. PEPT1 and PAT1 were expressed only in normal lung and prostate cells, respectively, but not in their cancerous counterparts. Inhibition of these transporters showed a significant decrease in PpIX production only in normal cells. PEPT1 and PAT1 transporter inhibitors could be possible new drugs to increase the specificity of ALA-PDT.

Citation Download Citation

Hung Wei Lai, Ryuta Sasaki, Shiro Usuki, Motowo Nakajima, Tohru Tanaka, and Shun-Ichiro Ogura "Novel strategy to increase specificity of ALA-induced PpIX accumulation through inhibition of transporters involved in ALA uptake", Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 110706I (7 August 2019); https://doi.org/10.1117/12.2524522

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