Non melanoma skin cancer (NMSC) can be seen as a multifaceted problem, considered primarily as a public health problem whose impact on society considers the morbidity and cost aspects of the treatment. It is a social problem, affecting all those who depend exclusively on the Brazilian public health system and need to wait months to receive any type of treatment. From the economic point of view, to treat all patients diagnosed with NMSC, it is necessary a big investment. Finally, the problem is logistical, since the territorial extension of Brazil and its population distribution do not enable the adequate care in all the places, which requires reallocation of patients from small cities to reference centers. Based on these facts, PDT for small skin lesions may be one of the best solutions from an economic point of view. Being a treatment that is easy for the training of professionals and enables to be performed in an ambulatory environment, minimizing post-treatment effects, this study shows that the cost of implementing the procedure on a large scale is extremely adequate for the national public health service. Using a strategy involving companies, national bank and medical partners, equipment, medication and protocols were tested in a multicenter study. With results collected over 5 years from a national program to implement PDT for non melanoma skin cancer over the Brazilian territory, we could reach a great economic evaluation of advances concerning the use of PDT for skin cancer.