Photodynamic therapy with a novel zinc phthalocyanine: an innovative approach to hepatocellular carcinoma treatment

Racheal O. Ogbodu; Bianca Nitzsche; Michael Höpfner

doi:10.1117/12.2522169

7 August 2019 Photodynamic therapy with a novel zinc phthalocyanine: an innovative approach to hepatocellular carcinoma treatment

Racheal O. Ogbodu, Bianca Nitzsche, Michael Höpfner

Author Affiliations +

Proceedings Volume 11070, 17th International Photodynamic Association World Congress; 11070AG (2019) https://doi.org/10.1117/12.2522169
Event: 17th International Photodynamic Association World Congress, 2019, Cambridge, Massachusetts, United States

Abstract

The photodynamic activity (PDT) of Tetra triethyleneoxysulfonyl zinc phthalocyanine (ZnPc) was studied on HepG2 and Huh-7 cells a typical example of hepatocellular carcinoma (HCC). HCC cells showed a dose dependent uptake of ZnPc. Photo-activation of ZnPc (0.5-5 µM) in HCC cells revealed strong PDT effects, leading to a dose-dependent decrease of cancer cells without any sign of re-proliferation and a dose-dependent increase in caspase-3-activity. By contrast, non-photoactivated ZnPc did not induce any cytotoxicity. The formation of ROS and free radical detected in the cytoplasm/nucleus of HCC cells and the expression of apoptotic proteins confirm the apoptotic mode of cell death.

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Racheal O. Ogbodu, Bianca Nitzsche, and Michael Höpfner "Photodynamic therapy with a novel zinc phthalocyanine: an innovative approach to hepatocellular carcinoma treatment", Proc. SPIE 11070, 17th International Photodynamic Association World Congress, 11070AG (7 August 2019); https://doi.org/10.1117/12.2522169

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