Design of a multi-modality salpingoscope for visualization of the ovary and oviducts

Jennifer K. Barton; Gabriella Romano; David Vega; Kelli C. Kiekens; Harrison T. Thurgood; Dominique B. Galvez; Orkhongua Batjargal; Yi-Hsin Ou; Khanh Kieu

doi:10.1117/12.2526768

19 July 2019 Design of a multi-modality salpingoscope for visualization of the ovary and oviducts

Jennifer K. Barton, Gabriella Romano, David Vega, Kelli C. Kiekens, Harrison T. Thurgood, Dominique B. Galvez, Orkhongua Batjargal, Yi-Hsin Ou, Khanh Kieu

Author Affiliations +

Proceedings Volume 11073, Clinical and Preclinical Optical Diagnostics II; 1107307 (2019) https://doi.org/10.1117/12.2526768
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

Recent discoveries suggest that ovarian cancer has its origins in the oviducts (Fallopian tubes) and may exist as intraepithelial carcinoma for up to 6 years. One route of access to the oviducts and ovaries is through the wall of the vagina. We have developed an approximately 3.8 mm diameter rigid salpingoscope for surveillance of high-risk women and early detection of ovarian cancer. The salpingoscope contains multiple advanced imaging modalities, as well as a channel for instillation of saline or dyes, and another channel for introduction of biopsy forceps. The single optical channel combines the modalities of multispectral fluorescence and reflectance wide-field imaging, multiphoton microscopy (MPM), and optical coherence tomography (OCT). Multiple modalities through a single channel are achieved by a novel lens system with dichroic coatings which create separate optical paths for visible wavelengths (low numerical aperture (NA) imaging) and near-infrared wavelengths (high NA imaging). A quartered piezoelectric tube actuator scans a dual-clad fiber with added mass to facilitate both relatively slow (OCT) and fast (wide field and MPM) scanning. Visible wavelength laser diodes are the source for wide field reflectance and fluorescence imaging, with remitted light collected through 12 high NA multimode fibers. A novel femtosecond laser with near-infrared output provides the source for OCT and MPM, with remitted light collected through the core and inner cladding of the dual-clad fiber, respectively. Detectors include high sensitivity photodiodes for wide field, a linear array with spectrometer for OCT, and photomultiplier tubes to collect twoand three-photon signals for MPM imaging.

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Jennifer K. Barton, Gabriella Romano, David Vega, Kelli C. Kiekens, Harrison T. Thurgood, Dominique B. Galvez, Orkhongua Batjargal, Yi-Hsin Ou, and Khanh Kieu "Design of a multi-modality salpingoscope for visualization of the ovary and oviducts", Proc. SPIE 11073, Clinical and Preclinical Optical Diagnostics II, 1107307 (19 July 2019); https://doi.org/10.1117/12.2526768

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