Time-domain diffuse correlation spectroscopy quantifies path-length-resolved dynamical properties of a layered turbid media

Saeed Samaei; Dawid Borycki; Michal Kacprzak; Piotr Sawosz; Adam Liebert

doi:10.1117/12.2527160

11 July 2019 Time-domain diffuse correlation spectroscopy quantifies path-length-resolved dynamical properties of a layered turbid media

Saeed Samaei, Dawid Borycki, Michal Kacprzak, Piotr Sawosz, Adam Liebert

Author Affiliations +

Proceedings Volume 11074, Diffuse Optical Spectroscopy and Imaging VII; 110740B (2019) https://doi.org/10.1117/12.2527160
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

We apply time-domain diffuse correlation spectroscopy (TD DCS) to quantify dynamics in a two-layer turbid phantom, where the top layer contains purely static, while bottom layer contains only dynamic scatterers. We demonstrate that the standard TD DCS processing is incapable to properly quantify dynamics at short sourcedetector distances (<1 cm) due to strong influence of the static layer. To solve this problem we introduce a novel model accompanied by the numerical noise-correction, which allows to properly recover the autocorrelation decay of the dynamic homogeneous medium hidden by the static turbid layer. Our approach can be thus beneficial for DCS applications in samples with mixed dynamics.

Citation Download Citation

Saeed Samaei, Dawid Borycki, Michal Kacprzak, Piotr Sawosz, and Adam Liebert "Time-domain diffuse correlation spectroscopy quantifies path-length-resolved dynamical properties of a layered turbid media", Proc. SPIE 11074, Diffuse Optical Spectroscopy and Imaging VII, 110740B (11 July 2019); https://doi.org/10.1117/12.2527160

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