Comparative study of quantitative methods to determine component concentration for water-free biotissue phantom

Ravshanjon Nazarov; Tianmiao Zhang; Mikhail Khodzitsky; Petr Demchenko

doi:10.1117/12.2525215

22 July 2019 Comparative study of quantitative methods to determine component concentration for water-free biotissue phantom

Ravshanjon Nazarov, Tianmiao Zhang, Mikhail Khodzitsky, Petr Demchenko

Author Affiliations +

Proceedings Volume 11075, Novel Biophotonics Techniques and Applications V; 110750Y (2019) https://doi.org/10.1117/12.2525215
Event: European Conferences on Biomedical Optics, 2019, Munich, Germany

Abstract

To evaluate, calibrate equipment, and check the safety of THz devices etc, biotissue phantom is needed for these purposes. Although various researches about biotissue phantom using water have been done, such phantoms are not ideal. Because of the evaporation of water, the optical properties of a phantom change as the time goes by, since THz radiation is very sensitive to the water concentration of the sample. We chose graphite as the substitute of water, and therefore the water-free biotissue phantom was developed to mimic the similar optical properties as human tissues. In order to determine the concentration of each component precisely, quantitative analysis is needed. In this work, we used several mathematical models of the effective medium theory, including the Polder and van Santen model, the Landau, Lifshitz, Looyenga model, the model of complex refractive index, and the Bruggeman model, to study the influence of different graphite concentrations on the refractive index of the water-free biotissue phantom. Phantoms with different graphite concentrations were simulated and 3 phantoms with different graphite concentrations were produced to evaluate the reliability of each model. The fabricated phantoms were then compared with stomach tissues. The result also shows the promise that by using the proper mathematical model, correct concentration can be calculated for other tissue phantom.

Citation Download Citation

Ravshanjon Nazarov, Tianmiao Zhang, Mikhail Khodzitsky, and Petr Demchenko "Comparative study of quantitative methods to determine component concentration for water-free biotissue phantom", Proc. SPIE 11075, Novel Biophotonics Techniques and Applications V, 110750Y (22 July 2019); https://doi.org/10.1117/12.2525215

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