Enantio-selective sensing using plasmonic racemic arrays (Conference Presentation)

Jose Garcia-Guirado; Mikael Svedendahl; Joaquim Puigdollers; Romain Quidant

doi:10.1117/12.2529365

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9 September 2019 Enantio-selective sensing using plasmonic racemic arrays (Conference Presentation)

Jose Garcia-Guirado, Mikael Svedendahl, Joaquim Puigdollers, Romain Quidant

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Proceedings Volume 11082, Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XVII; 1108212 (2019) https://doi.org/10.1117/12.2529365
Event: SPIE Nanoscience + Engineering, 2019, San Diego, California, United States

Abstract

We present a novel plasmonic sensor configuration that allows the discrimination of chiral molecules. The sensor consists of handed gold nanostructures of gammadion shape, distributed in a racemic (50/50 mixture) matrix with C4 symmetry. Its optical response enhances the interaction with molecules thus circular dichroism can be measured in the visible range. The bare sensors exhibit a flat CD signal, providing background-free CD measurements for molecular detection. We have used a chiral molecular model based on L-, D-, and the racemic mixture of phenylalanine, which allows us to evaluate the opposite chiral effects while having a reference system. Additionally, we have used molecular thermal evaporation technique to deposit a dense molecular layer on top of the sensors in a controllable and reproducible way. Our results show the discrimination of phenylalanine enantiomers through positive or negative peaks while the racemic mixture shows a flat signal. In addition, we present preliminary results that show that this approach is also suitable for microfluidics systems with a much lower density of chiral molecules.

Conference Presentation

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Jose Garcia-Guirado, Mikael Svedendahl, Joaquim Puigdollers, and Romain Quidant "Enantio-selective sensing using plasmonic racemic arrays (Conference Presentation)", Proc. SPIE 11082, Plasmonics: Design, Materials, Fabrication, Characterization, and Applications XVII, 1108212 (9 September 2019); https://doi.org/10.1117/12.2529365

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