Improved regressions with convolutional neural networks for surface enhanced Raman scattering sensing of metabolite biomarkers

William John Thrift; Cuong Quoc Nguyen; Junlin Wang; Jason Ernest Kahn; Ruijun Dong; Andrew Benjamin Laird; Regina Ragan

doi:10.1117/12.2535410

3 September 2019 Improved regressions with convolutional neural networks for surface enhanced Raman scattering sensing of metabolite biomarkers

William John Thrift, Cuong Quoc Nguyen, Junlin Wang, Jason Ernest Kahn, Ruijun Dong, Andrew Benjamin Laird, Regina Ragan

Author Affiliations +

Proceedings Volume 11089, Nanoengineering: Fabrication, Properties, Optics, Thin Films, and Devices XVI; 1108907 (2019) https://doi.org/10.1117/12.2535410
Event: SPIE Nanoscience + Engineering, 2019, San Diego, California, United States

Abstract

Surface enhanced Raman scattering (SERS) is a vibrational spectroscopy method that enables the quantification of the concentration of small molecules. SERS sensing has been demonstrated in a wide variety of applications, from explosive and drug detection, to monitoring of bacteria growth. Underpinning SERS sensing are the sensor surfaces that are composed of vast quantities of metal nanostructures which confine light into small gaps called “hotspots”, enhancing Raman scattering. While these surfaces are essential for increasing Raman scattering intensity so that analyte signal may be observed in small concentrations, they introduce signal variations due to spatial distributions of Raman enhancement and hotspot volume. In this work, we introduce a convolutional neural network model that improves concentration regressions in SERS sensors by learning the distributions of sensor surface dependent latent variables. We demonstrate that this model significantly improves predictions compared to a traditional multilayer perceptron approach, and that the model uses analyte spectral information and is capable of reasonable interpolations.

Citation Download Citation

William John Thrift, Cuong Quoc Nguyen, Junlin Wang, Jason Ernest Kahn, Ruijun Dong, Andrew Benjamin Laird, and Regina Ragan "Improved regressions with convolutional neural networks for surface enhanced Raman scattering sensing of metabolite biomarkers", Proc. SPIE 11089, Nanoengineering: Fabrication, Properties, Optics, Thin Films, and Devices XVI, 1108907 (3 September 2019); https://doi.org/10.1117/12.2535410

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