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30 December 2019 Quantitative biosensing by surface-enhanced Raman scattering
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Abstract
Since its discovery in the 1970s, surface-enhanced Raman scattering (SERS) has attracted interest as a sensitive technique for detecting a wide range of analytes. However, SERS is a complex physicochemical phenomenon and tends to suffer from poor levels of reproducibility, which has hindered its translation into practical applications. Here we confirm that the low wavenumber pseudoband arising from the interaction between the edge filter and the elastically scattered light from the laser excitation can be used to perform "hotspot" normalisation of SERS spectra. Together with judicious use of resonant Raman scattering and/or careful control of the surface chemistry, this breakthrough in spectral data processing can address many of the challenges encountered when developing a quantitative SERS-based assay.
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Md Abdullah Al Mamun, Nerida A. Cole, Saulius Juodkazis, and Paul R. Stoddart "Quantitative biosensing by surface-enhanced Raman scattering", Proc. SPIE 11202, Biophotonics Australasia 2019, 112020W (30 December 2019); https://doi.org/10.1117/12.2541321
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