Two types of tunable polarization-independent two-dimensional grating guided-mode resonance (GMR) filters are proposed and analyzed. The GMR filters are based on 2D crossed sinusoidal diffraction grating to archive polarizationindependent reflectance spectra and can be fabricated by using low-cost nanoimprinting process. The first GMR filter structure is consisted of three layers, including a planar waveguide, a low refractive index separation layer, and a nanoimprinting grating layer and the other has only two layers. The diffraction efficiencies are investigated by rigorous coupled-wave analysis (RCWA) method. For these two filters, by altering the incident and azimuth angle, the resonance wavelength of the proposed GMR filter is tunable and polarization-independent, and TE- and TM-polarized incident light can have the same diffraction efficiencies by adjusting the azimuth angle. For the first GMR structure with a grating period of 416 nm, the simulation results show that when the incident angle varying from 15° to 19° and the azimuth angle is set at 34°, the tunability in resonance wavelength is at a slope of 3.8 nm/degree. At the incident angle of 17° and azimuthal angle of 34°, the lowest difference of the diffraction efficiencies between two polarizations is approximately 0.23% at the resonance wavelength of 686.3 nm. The average diffraction efficiencies are 45.33% (TE polarization) and 44.94% (TM polarization). For the second GMR structure with a grating period of 555 nm, the simulation results show that when the incident angle varying from the same 15° to 19° and the azimuth angle is set at 38°, the tunability in resonance wavelength is at a slope of 6.5 nm/degree.