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24 February 2020 Clinical multimodal multiphoton tomography of pigmented skin lesions with an ultracompact femtosecond fiber laser
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Abstract
Multiphoton tomography (MPT) has become a high-resolution label-free clinical imaging tool to obtain optical skin biopsies for rapid in vivo histology. Here, we report on the novel multimodal multiphoton tomograph MPT compact based on a chiller-free ultracompact 80 MHz femtosecond fiber laser operating at 780 nm. The 360°-measurement head contains the laser head and multiple photon detectors for (i) autofluorescence (AF) imaging, (ii) fluorescence lifetime imaging (FLIM) for optical metabolic imaging (OMI) and melanin detection, (iii) second harmonic imaging (SHG) of collagen, (iv) confocal reflection microscopy (CRM), and (v) white-light imaging (dermoscopy). Preliminary results of an ongoing multicenter clinical study in patients with suspicious pigmented lesions in two hospitals are presented.
© (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Karsten König, Ana Batista, Michael Zieger, Martin Kaatz, Holger Hänssle, Christine Fink, and Hans Georg Breunig "Clinical multimodal multiphoton tomography of pigmented skin lesions with an ultracompact femtosecond fiber laser", Proc. SPIE 11211, Photonics in Dermatology and Plastic Surgery 2020, 112110E (24 February 2020); https://doi.org/10.1117/12.2542322
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