Confocal mimics hematoxylin and eosin: recent technical development in translation (Conference Presentation)

Daniel S. Gareau; John A. Carucci; Alba G. Mülberger; Samantha R Lish

doi:10.1117/12.2551788

6 March 2020 Confocal mimics hematoxylin and eosin: recent technical development in translation (Conference Presentation)

Daniel S. Gareau, John A. Carucci, Alba G. Mülberger, Samantha R Lish

Author Affiliations +

Proceedings Volume 11213, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2020; 112130C (2020) https://doi.org/10.1117/12.2551788
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

There us a significant need for point of care pathology technologies that provide microscopic resolution without the processing that is typically required. 20,000,000 biopsies per year in the USA each present a week delay in cancer care while they are processed and analyzed. Bedside confocal microscopy offers an alternative but has typically been difficult to perform due to the irregularity of surgical specimens and reflectance artifact. The sample irregularity makes it hard to put the correct plane of tissue in the conjugate focal plane and the reflectance artifact that arises from the glass/water interface at the window surface onto which the sample is pressed, gives the appearance of tissue outside the specimen (where there is no tissue, false positive for tissue). We present newly developed computational and electromechanical solutions to these problems and analysis of specimens under our clinical research study.

Conference Presentation

Citation Download Citation

Daniel S. Gareau, John A. Carucci, Alba G. Mülberger, and Samantha R Lish "Confocal mimics hematoxylin and eosin: recent technical development in translation (Conference Presentation)", Proc. SPIE 11213, Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2020, 112130C (6 March 2020); https://doi.org/10.1117/12.2551788

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