CONFERENCE PROCEEDINGS
Advanced Search
Home > Proceedings > Volume 11215 > Article
Presentation
9 March 2020 Biomechanical analysis of the embryonic mouse heart by optogenetic control (Conference Presentation)
Andrew L. Lopez III, Shang Wang, Irina V. Larina
Author Affiliations +
Proceedings Volume 11215, Diagnostic and Therapeutic Applications of Light in Cardiology 2020; 112150J (2020) https://doi.org/10.1117/12.2548853
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
The role of biomechanical signaling is well accepted as a modulator of cardiac cell behavior and a requirement for cardiac morphogenesis. However, the small, fragile nature of the embryonic heart makes it difficult to determine transient mechanical homeostasis during heart development and search for causal links between biomechanical forces and cardiac cell behavior in vivo. Our work focuses on characterizing the regulatory role of biomechanical signals to direct cardiac morphogenesis and cell behavior. Towards this end, we have successfully established cardiac optogenetics to control heartbeat frequency in the embryonic mouse heart for the first time. We will combine this approach with second harmonic generation, an unbiased imaging approach to detect collagen deposition. Using optogenetic cardiac pacing and second harmonic generation imaging, we will look at how changes in heart biomechanics are consequential in the deposition and organization of cardiac collagen.
Conference Presentation
© (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Citation Download Citation
Andrew L. Lopez III, Shang Wang, and Irina V. Larina "Biomechanical analysis of the embryonic mouse heart by optogenetic control (Conference Presentation)", Proc. SPIE 11215, Diagnostic and Therapeutic Applications of Light in Cardiology 2020, 112150J (9 March 2020); https://doi.org/10.1117/12.2548853
ACCESS THE FULL ARTICLE
ORGANIZATIONAL
Sign in with credentials provided by your organization.
INSTITUTIONAL
Select your institution to access the SPIE Digital Library.
SELECT YOUR INSTITUTION
PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.
PERSONAL SIGN IN
No SPIE Account? Create one
PURCHASE THIS CONTENT
SUBSCRIBE TO DIGITAL LIBRARY
50 downloads per 1-year subscription
Members: $195
Non-members: $335 ADD TO CART
25 downloads per 1 - year subscription
Members: $145
Non-members: $250 ADD TO CART
PURCHASE SINGLE ARTICLE
Includes PDF, HTML & Video, when available
Members: $17.00
Non-members: $21.00 ADD TO CART
PROCEEDINGS
 PRESENTATION
WATCH
PRESENTATION SAVE TO MY LIBRARY
GET CITATION
Advertisement
Advertisement
KEYWORDS
Heart
Optogenetics
Biological research
Collagen
Harmonic generation
In vivo imaging
Integration
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top