Dynamic range enhancement for diffuse optical spectroscopy in breast scanning applications

Mi Zhou; Zhi Yih Lim; Farid Golnaraghi; Majid Shokoufi

doi:10.1117/12.2546794

2 March 2020 Dynamic range enhancement for diffuse optical spectroscopy in breast scanning applications

Mi Zhou, Zhi Yih Lim, Farid Golnaraghi, Majid Shokoufi

Proceedings Volume 11216, Multiscale Imaging and Spectroscopy; 1121611 (2020) https://doi.org/10.1117/12.2546794
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Diffuse Optical Breast Scanner (DOB-Scan) probe utilizes a linear charge-coupled device (CCD) array as the detector, measuring back-scattered light intensity above the breast tissue to create cross-sectional concentration images for different constituents. The response received at each pixel of the sensor is determined by optical properties of the scattering medium, source-detector distance, integration time of CCD array, and intensity of the light source. However, the performance of the probe is limited by the inherent electronic properties of CCD array, which cause saturation at high response region and high noise level at low response region. In this paper, an algorithm to enhance the dynamic range of the CCD array is presented. The objective is to maximize the dynamic range of the CCD array without any data loss while minimizing the noise-to-signal ratio where the response of the CCD array is relatively low. The desired output can be achieved by capturing multiple sets of data with different integration time and light intensity settings, ensuring the best CCD performance in each pixel range of interest. The profile of CCD array’s linearity and optical power measurement of the light source allow different sets of data to be translated into the same scale and joined accordingly into one. A series of phantom studies are conducted and confirm the feasibility of the probe’s dynamic range intensification.

Citation Download Citation

Mi Zhou, Zhi Yih Lim, Farid Golnaraghi, and Majid Shokoufi "Dynamic range enhancement for diffuse optical spectroscopy in breast scanning applications", Proc. SPIE 11216, Multiscale Imaging and Spectroscopy, 1121611 (2 March 2020); https://doi.org/10.1117/12.2546794

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KEYWORDS

Reflectivity

Charge-coupled devices

Tissue optics

Optical properties

Diffuse optical spectroscopy

Light emitting diodes

CCD image sensors

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