In-vivo, non-contact, cellular resolution imaging of the human limbus with line-field SD-OCT at 2.5 kHz frame rate (Conference Presentation)

Le Han; Zohreh Hosseinaee; Lin Kun Chen; Kostadinka Bizheva

doi:10.1117/12.2548638

9 March 2020 In-vivo, non-contact, cellular resolution imaging of the human limbus with line-field SD-OCT at 2.5 kHz frame rate (Conference Presentation)

Le Han, Zohreh Hosseinaee, Lin Kun Chen, Kostadinka Bizheva

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Proceedings Volume 11218, Ophthalmic Technologies XXX; 112180O (2020) https://doi.org/10.1117/12.2548638
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Currently, clinical in-vivo imaging of the human limbus cellular structure is only possible with in-vivo confocal microscopy (IVCM). However, IVCM requires physical contact with the imaged object, and may cause incidental tearing or inflammation of the limbal tissue. We present a line-field, spectral-domain OCT system (LF-SD-OCT) that can generate volumetric, cellular resolution images of biological tissue in-vivo and without contact. The system provides 1.7 µm axial and 2.2 × 3.1 µm lateral resolution in tissue and 2.5 kHz frame rate. The quality of healthy human limbus images acquired with LF-SD-OCT is comparable to that of IVCM.

Conference Presentation

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Le Han, Zohreh Hosseinaee, Lin Kun Chen, and Kostadinka Bizheva "In-vivo, non-contact, cellular resolution imaging of the human limbus with line-field SD-OCT at 2.5 kHz frame rate (Conference Presentation)", Proc. SPIE 11218, Ophthalmic Technologies XXX, 112180O (9 March 2020); https://doi.org/10.1117/12.2548638

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KEYWORDS

In vivo imaging

Image resolution

Optical coherence tomography

Tissues

Coherence (optics)

Confocal microscopy

Inflammation

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