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9 March 2020 Phase-decorrelation OCT for detection of corneal softening in an enzymatic ex vivo model of ectasia (Conference Presentation)
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Proceedings Volume 11218, Ophthalmic Technologies XXX; 112180W (2020) https://doi.org/10.1117/12.2546557
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Nearly all benchtop studies of corneal biomechanics have relied on protocols which stiffen the cornea, such as riboflavin-UV crosslinking, as a way of providing contrast and validation of biomechanical measurements. However, there are strong clinical motivations to detect softening of the cornea. In this work, we present the evidence that phase-decorrelation OCT (PhD-OCT) is able to detect a small degree of corneal softening due to enzymatic digestion. This benchtop study supports the idea that PhD-OCT may detect keratoconus and early ectasia clinically.
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Brecken J. Blackburn, John P. Murray, Matthew R. Ford, Michael W. Jenkins, William J. Dupps Jr., and Andrew M. Rollins "Phase-decorrelation OCT for detection of corneal softening in an enzymatic ex vivo model of ectasia (Conference Presentation)", Proc. SPIE 11218, Ophthalmic Technologies XXX, 112180W (9 March 2020); https://doi.org/10.1117/12.2546557
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