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9 March 2020 Characterization of retinal changes in a mouse model of Alzheimer’s disease using multi-contrast optical coherence tomography (Conference Presentation)
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Proceedings Volume 11218, Ophthalmic Technologies XXX; 112181C (2020) https://doi.org/10.1117/12.2548412
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Recent Alzheimer’s disease (AD) studies have focused on retinal analysis, as the retina is the only part of the central nervous system which can be imaged non-invasively by optical methods. The appearance of the retina of the APP/PS1 mouse model of AD was therefore evaluated by a custom-built multi-contrast optical coherence tomography (OCT) system. By visualizing retinal changes over a range of ages in intensity-, polarization- and motion-based contrast modes simultaneously, observations in the retina were documented and compared to both retinal whole-mounts and conventional histological sections. The data was also correlated to the cortical amyloid beta plaque load.
Conference Presentation
© (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Bernhard Baumann, Danielle J. Harper, Antonia Lichtenegger, Johanna Gesperger, Tanja Himmel, Martina Muck, Conrad W. Merkle, Pablo Eugui, Stefan Kummer, Adelheid Woehrer, Martin Glösmann, and Marco Augustin "Characterization of retinal changes in a mouse model of Alzheimer’s disease using multi-contrast optical coherence tomography (Conference Presentation)", Proc. SPIE 11218, Ophthalmic Technologies XXX, 112181C (9 March 2020); https://doi.org/10.1117/12.2548412
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