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19 February 2020 Estimating retinal vascular permeability from fluorescein videoangiography data despite signal saturation in large vessels in low-dynamic range systems
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Proceedings Volume 11218, Ophthalmic Technologies XXX; 1121823 (2020) https://doi.org/10.1117/12.2546442
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Fluorescein videoangiography is often used to visualize diabetic retinopathy (DR), a degenerative disease characterized by degradation of retinal blood vessels. However, more sensitive and quantitative measures of increased vessel permeability in the asymptomatic phase of DR (non-proliferative DR) could help identify patients who would benefit from therapeutic intervention to avoid vision loss. Here, a modified “adiabatic approximation to the tissue-homogeneity model” was shown in simulations and rat experiments to estimate extraction fraction within a 20%-error for physiological ranges of vascular permeability expected in nonproliferative DR, even in low-dynamic-range (8-bit) fluorescein imaging systems that are standard in many institutes.
© (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Elif Kayaalp Nalbant, Wenqiang Liu, Hande Pehlivan, Shailee Shah, Anessa Puskar, Meghna Sampath, William F. Mieler, Jennifer J. Kang-Mieler, and Kenneth M. Tichauer "Estimating retinal vascular permeability from fluorescein videoangiography data despite signal saturation in large vessels in low-dynamic range systems", Proc. SPIE 11218, Ophthalmic Technologies XXX, 1121823 (19 February 2020); https://doi.org/10.1117/12.2546442
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