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10 March 2020 Is PDT-based metastatic reduction a consequence of local tumor control or a true abscopal effect in immunodeficient mice? (Conference Presentation)
Tayyaba Hasan
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Proceedings Volume 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX; 1122003 (2020) https://doi.org/10.1117/12.2549954
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Despite the concept of Photodynamic Therapy (PDT) being over a century old and regulatory approvals being worldwide for limited indications, PDT is not as broadly used for cancer treatment as promising pre-clinical observations might indicate. One of reasons maybe that it is primarily viewed as a local therapy, yet it is used in patients with advanced disease often in the palliative setting and with metastatic disease. The effect of PDT on metastatic disease has not been studied in any detail. We have reported both an increase and a decrease of metastatic burden. Increased survival in tumor bearing mice along with a decrease in metastatic burden has been demonstrated in both immune competent and immune deficient mice. While in immune competent mice this observation has been attributed to the activation of the mouse immune system, the explanation is less clear in immune suppressed mice (patients?).
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Tayyaba Hasan "Is PDT-based metastatic reduction a consequence of local tumor control or a true abscopal effect in immunodeficient mice? (Conference Presentation)", Proc. SPIE 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX, 1122003 (10 March 2020); https://doi.org/10.1117/12.2549954
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KEYWORDS
Photodynamic therapy
Tumors
Cancer
Oncology
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