Tribulations in medicine:  designing and implementing a trial of PDT plus vitamin D3 for high-grade anal dysplasia and microinvasive anal cancer (Conference Presentation)

Keith A. Cengel; Timothy C. Zhu; Sally McNulty; Edgar Ben-Josef; Theresa M. Busch

doi:10.1117/12.2552334

10 March 2020 Tribulations in medicine: designing and implementing a trial of PDT plus vitamin D3 for high-grade anal dysplasia and microinvasive anal cancer (Conference Presentation)

Keith A. Cengel, Timothy C. Zhu, Sally McNulty, Edgar Ben-Josef, Theresa M. Busch

Author Affiliations +

Proceedings Volume 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX; 112200H (2020) https://doi.org/10.1117/12.2552334
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We have initiated a clinical trial to test the hypothesis that we hypothesize that PDT with the photosensitizing pro-drug ALA and vitamin D3 can be applied to treat anal (pre)malignancy with acceptable toxicity and light dose delivery (NCT02698293) . Here, we report on the design of the trial, a custom apparatus to deliver light while measuring PpIX fluorescence and tissue optical properties, validation of apparatus and initial toxicity in the first treated patients.

Conference Presentation

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Keith A. Cengel, Timothy C. Zhu, Sally McNulty, Edgar Ben-Josef, and Theresa M. Busch "Tribulations in medicine: designing and implementing a trial of PDT plus vitamin D3 for high-grade anal dysplasia and microinvasive anal cancer (Conference Presentation)", Proc. SPIE 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX, 112200H (10 March 2020); https://doi.org/10.1117/12.2552334

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