Reactive oxygen species explicit dosimetry for the evaluations of treatment efficiency of single and fractionated ALA-mediated photodynamic therapy

Yi Hong Ong; Tianqi Sheng; Theresa M. Busch; Timothy C. Zhu

doi:10.1117/12.2546425

25 February 2020 Reactive oxygen species explicit dosimetry for the evaluations of treatment efficiency of single and fractionated ALA-mediated photodynamic therapy

Yi Hong Ong, Tianqi Sheng, Theresa M. Busch, Timothy C. Zhu

Author Affiliations +

Proceedings Volume 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX; 112200R (2020) https://doi.org/10.1117/12.2546425
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Reactive oxygen species explicit dosimetry (ROSED) has been recently developed and demonstrated to be able to better correlate with treatment outcome in both preclinical type I and type II PDT. ROSED involves direct measurements of in-vivo light fluence (rate), in-vivo photosensitizer concentration and tissue oxygenation to calculate for reacted ROS concentration ([ROS]_rx) generated by PDT processes. In this study, we demonstrated ROSED in ALA-mediated PDT for mice bearing radiation-induced fibrosacorma (RIF) tumor. PDT treatments were performed using single or fractionated illumination to a same total fluence of 140Jcm^-2. The effects of light fractionation on the total reacted [ROS]_rx and treatment outcomes were evaluated.

Citation Download Citation

Yi Hong Ong, Tianqi Sheng, Theresa M. Busch, and Timothy C. Zhu "Reactive oxygen species explicit dosimetry for the evaluations of treatment efficiency of single and fractionated ALA-mediated photodynamic therapy", Proc. SPIE 11220, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXIX, 112200R (25 February 2020); https://doi.org/10.1117/12.2546425

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