Indocyanine-green matching phantom for fluorescence-guided imaging system characterization and performance monitoring (Conference Presentation)

Alberto J. Ruiz; Mindy Wu; Ethan P. M. LaRochelle; Dimitris Gorpas; Joshua Pfefer; Vasilis Ntziachristos; Brian W. Pogue

doi:10.1117/12.2547056

10 March 2020 Indocyanine-green matching phantom for fluorescence-guided imaging system characterization and performance monitoring (Conference Presentation)

Alberto J. Ruiz, Mindy Wu, Ethan P. M. LaRochelle, Dimitris Gorpas, Joshua Pfefer, Vasilis Ntziachristos, Brian W. Pogue

Author Affiliations +

Proceedings Volume 11222, Molecular-Guided Surgery: Molecules, Devices, and Applications VI; 112220D (2020) https://doi.org/10.1117/12.2547056
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Fluorescence imaging for surgical guidance is a proven modality that allows for visualization of fluorescent markers in numerous biological imaging applications. As the field continues to develop there is an urgent need for fluorescence-imaging standards that enable system characterization and performance monitoring. Here, we present a long-term stable standard that mimics indocynine green (ICG) spectral behavior and is capable of probing the sensitivity of commercially available imaging systems. The standard is composed of three different tests: a varying concentration sensitivity test (0.1nM-3000nM), a tissue-equivalent-depth sensitivity test (0.2mm-7mm), and a 1951 USFA fluorescence resolution test. The fluorescence standard platform developed can incorporate 3-D printing with tissue-equivalent layers, enabling a wide variety of anatomical-specific designs. The manufacturing capabilities developed allow for incorporation of different fluorophores for applications beyond ICG and NIR.

Conference Presentation

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Alberto J. Ruiz, Mindy Wu, Ethan P. M. LaRochelle, Dimitris Gorpas, Joshua Pfefer, Vasilis Ntziachristos, and Brian W. Pogue "Indocyanine-green matching phantom for fluorescence-guided imaging system characterization and performance monitoring (Conference Presentation)", Proc. SPIE 11222, Molecular-Guided Surgery: Molecules, Devices, and Applications VI, 112220D (10 March 2020); https://doi.org/10.1117/12.2547056

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KEYWORDS

Luminescence

Standards development

Imaging systems

Manufacturing

Tissues

3D printing

3D imaging standards

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