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10 March 2020 Tumor margin assessment using frozen sections can be improved by paired-agent imaging (Conference Presentation)
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Abstract
During resection of head and neck cancers, surgeons collect multiple small tissue samples from the excision wound bed for “frozen section” analysis by a clinical pathologist to determine clear margins. However, this process is disruptive to work flow, time-consuming, and expensive. We have validated Paired-Agent Imaging (PAI) in in vivo xenograft models using epidermal growth factor receptor and demonstrated that PAI exhibits higher diagnostic accuracy targeted agent alone – tested in both fresh tissue (~3-mm) and frozen sections (10-m). Here PAI will be extended to screening of tissue biopsies to quantify tumor burden in comparison to standard frozen section pathology.
Conference Presentation
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Kimberley S. Samkoe, Cheng Wang, Eunice Chen, Laura Tafe, and Kenneth Tichauer "Tumor margin assessment using frozen sections can be improved by paired-agent imaging (Conference Presentation)", Proc. SPIE 11222, Molecular-Guided Surgery: Molecules, Devices, and Applications VI, 112220N (10 March 2020); https://doi.org/10.1117/12.2547011
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