Detection of cortical optical changes during seizure activity using optical coherence tomography (Conference Presentation)

Danielle Ornelas; Md. Hasan; Jenny Szu; Oscar Gonzalez; Timothy Myers; Koji Hirota; Melissa Eberle; Maksim Bazhenov; Devin Binder; B. Hyle Park

doi:10.1117/12.2546710

9 March 2020 Detection of cortical optical changes during seizure activity using optical coherence tomography (Conference Presentation)

Danielle Ornelas, Md. Hasan, Jenny Szu, Oscar Gonzalez, Timothy Myers, Koji Hirota, Melissa Eberle, Maksim Bazhenov, Devin Binder, B. Hyle Park

Author Affiliations +

Proceedings Volume 11226, Neural Imaging and Sensing 2020; 112260U (2020) https://doi.org/10.1117/12.2546710
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Optical coherence tomography (OCT) is a label-free, high resolution, and minimally invasive imaging technique that can produce depth-resolved cross-sectional and 3D images. We sought to examine non-vascular depth-dependent optical changes directly related to neural activity in the brain using OCT. Results of this study show a significant temporal correlation between non-vascular decrease in attenuation in ex vivo and in vivo seizure models and increased electrical activity during seizure. This study allows for a more thorough and biologically relevant analysis of the optical signature of seizure activity ex vivo and in vivo using OCT.

Conference Presentation

Citation Download Citation

Danielle Ornelas, Md. Hasan, Jenny Szu, Oscar Gonzalez, Timothy Myers, Koji Hirota, Melissa Eberle, Maksim Bazhenov, Devin Binder, and B. Hyle Park "Detection of cortical optical changes during seizure activity using optical coherence tomography (Conference Presentation)", Proc. SPIE 11226, Neural Imaging and Sensing 2020, 112260U (9 March 2020); https://doi.org/10.1117/12.2546710

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