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9 March 2020 Heartbeat recovery after cardiac arrest and association of maximum pace-able heart rate with aging via optogenetic pacing and OCM imaging of Drosophila (Conference Presentation)
Jing Men, Airong Li, Zhiwen Yang, Jixu Yu, Rudolph Tanzi, Chao Zhou
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Proceedings Volume 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV; 112281X (2020) https://doi.org/10.1117/12.2549151
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
Here, we established NpHR Drosophila model, and demonstrated a heartbeat recovery process after red-light excitation induced cardiac arrest. The maximum heart rate (maxHR) and heart rate recovery time increased with prolonged cardiac arrest. ReaChR fly model was also developed to study the relationship of maximum pace-able heart rate (maxPR) with aging. Older flies showed decreased maxPR. An optical coherence microscopy (OCM) system was used to monitor the heart rate in vivo and in real time. The maxHR, recovery time, and maxPR could become promising indicators of cardiac health for various cardiac studies via Drosophila models in future.
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Jing Men, Airong Li, Zhiwen Yang, Jixu Yu, Rudolph Tanzi, and Chao Zhou "Heartbeat recovery after cardiac arrest and association of maximum pace-able heart rate with aging via optogenetic pacing and OCM imaging of Drosophila (Conference Presentation)", Proc. SPIE 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 112281X (9 March 2020); https://doi.org/10.1117/12.2549151
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KEYWORDS
Heart
Optogenetics
In vivo imaging
Optical coherence microscopy
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