Gold nanobipyramds as optical coherence tomography contrast agents in the second near infrared window for multiplexing study of tumor lymphatic flows (Conference Presentation)

Peng Si; Saba Shevidi; Edwin Yuan; Ke Yuan; Ziv Lautman; Stefanie S. Jeffrey; George W. Sledge; Adam de la Zerda

doi:10.1117/12.2548906

9 March 2020 Gold nanobipyramds as optical coherence tomography contrast agents in the second near infrared window for multiplexing study of tumor lymphatic flows (Conference Presentation)

Peng Si, Saba Shevidi, Edwin Yuan, Ke Yuan, Ziv Lautman, Stefanie S. Jeffrey, George W. Sledge, Adam de la Zerda

Author Affiliations +

Proceedings Volume 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV; 1122829 (2020) https://doi.org/10.1117/12.2548906
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Developing suitable contrast agents is essential for multiplexed optical coherence tomography (OCT), which allows simultaneous imaging of different biomarkers, cells and flows in living subjects. However, few OCT contrast agents have shown multiplexing capability, especially in the second near infrared (NIR-II) window. Here we demonstrate that using gold nanobipyramds as OCT contrast agents, two separate lymph flows can be visualized simultaneously in a live mouse in the NIR-II window. We concurrently traced lymph flows draining from a melanoma tumor and peritumoral tissue upstream of the melanoma, showing these flows exhibit distinct drainage patterns and merge into the same lymph node.

Conference Presentation

Citation Download Citation

Peng Si, Saba Shevidi, Edwin Yuan, Ke Yuan, Ziv Lautman, Stefanie S. Jeffrey, George W. Sledge, and Adam de la Zerda "Gold nanobipyramds as optical coherence tomography contrast agents in the second near infrared window for multiplexing study of tumor lymphatic flows (Conference Presentation)", Proc. SPIE 11228, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXIV, 1122829 (9 March 2020); https://doi.org/10.1117/12.2548906

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